Homocysteine and post-stroke cognitive decline

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Stroke and Cognitive Decline.

Stroke and cognitive impairment are common among older persons.1 It is estimated that the lifetime risk for stroke is approximately 1 in 5 for women and 1 in 6 for men,2 and almost one-third of persons with stroke, which typically may involve motor, sensory, or other deficits, may have a significant degree of cognitive impairment within several months of the event.1 Furthermore, silent strokes ...

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Trajectory of Cognitive Decline After Incident Stroke.

IMPORTANCE Cognitive decline is a major cause of disability in stroke survivors. The magnitude of survivors' cognitive changes after stroke is uncertain. OBJECTIVE To measure changes in cognitive function among survivors of incident stroke, controlling for their prestroke cognitive trajectories. DESIGN, SETTING, AND PARTICIPANTS Prospective study of 23,572 participants 45 years or older wit...

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Homocysteine and stroke.

During the past year epidemiological studies have linked elevated plasma total homocysteine concentrations with an increased risk of ischaemic stroke because of arterial disease. Laboratory studies have further explored the mitogenic effects of total homocysteine on vascular smooth muscle, and cytotoxic and thrombophilic effects on vascular endothelium. Also, a clinical trial has shown that low...

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Homocysteine, stroke, and dementia.

The increase in aging population worldwide is expected to cause an elevation in the prevalence of vascular diseases, including atherosclerosis, hypertension, diabetes mellitus, and hyperlipidemia, as well as their consequences: ischemic heart disease, peripheral vascular disease, and stroke. This will unavoidably result in an increase in the frequency of vascular dementia, which will only be en...

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Decline in changing Montreal Cognitive Assessment (MoCA) scores is associated with post-stroke cognitive decline determined by a formal neuropsychological evaluation

OBJECTIVES We aimed to examine changes in the Montreal Cognitive Assessment (MoCA) and Mini-Mental State Examination (MMSE) scores within a one-year period after stroke/transient ischemic attack (TIA) in associating cognitive decline determined by a formal neuropsychological test battery. METHODS Patients with ischemic stroke/TIA received MoCA and MMSE at baseline within 14 days after stroke/...

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ژورنال

عنوان ژورنال: Age and Ageing

سال: 2007

ISSN: 0002-0729,1468-2834

DOI: 10.1093/ageing/afm006